For what reason are mast cell modifiers used in asthma treatment?

Mast cell modifiers, such as cromolyn sodium and nedocromil, are primarily used in asthma treatment to decrease airway reactivity. This class of medications works by stabilizing mast cells, which are involved in the inflammatory response associated with asthma. By preventing these cells from releasing histamine and other inflammatory mediators, mast cell modifiers help reduce bronchoconstriction and airway hyperreactivity triggered by allergens and other stimuli.

These medications are particularly useful for their preventive role rather than providing immediate relief during an acute asthma attack. Therefore, while they may help in reducing the frequency of asthma exacerbations by controlling underlying inflammation and reactivity, they do not directly relieve acute symptoms, improve lung capacity, or enhance bronchodilation in the same way as rescue inhalers or other bronchodilators do.