In the case of ovarian disorders causing secondary amenorrhea, what hormonal imbalance is expected?

In cases of ovarian disorders leading to secondary amenorrhea, the expected hormonal profile typically shows decreased estradiol levels accompanied by increased follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This pattern occurs because ovarian dysfunction leads to insufficient production of estradiol due to impaired follicular development or loss of ovarian reserve. As a result, the negative feedback mechanism on the pituitary gland is disrupted, leading to increased secretion of FSH and LH as the body attempts to stimulate the ovaries to produce more hormones.

This hormonal imbalance is characteristic of conditions such as premature ovarian failure, primary ovarian insufficiency, or other forms of ovarian dysfunction. These conditions can result in an inadequate estrogenic environment, which is necessary for the regular menstrual cycle, thus causing amenorrhea.