What is the first-line treatment for acute pericarditis?

The first-line treatment for acute pericarditis is typically NSAIDs or aspirin. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or aspirin are effective in reducing inflammation and relieving pain associated with acute pericarditis. The rationale for using these medications stems from their anti-inflammatory properties, which can help alleviate the symptoms caused by the inflamed pericardium.

In addition to symptom relief, NSAIDs can help prevent the recurrence of pericarditis when administered properly. Aspirin, in particular, is often considered safe and effective for this condition. It's important to note that while other treatment options are available, such as corticosteroids for more severe or refractory cases, they are not typically the first choice due to concerns about side effects and the potential for delayed resolution of symptoms.

Colchicine is another medication that may be used in conjunction with NSAIDs for recurrent acute pericarditis or as an alternative, particularly in cases where NSAIDs are contraindicated or not tolerated. However, it does not serve as the first-line treatment in acute cases. Steroids might be utilized for specific indications where inflammation is particularly severe or persistent, but their use as first-line therapy is often avoided to prevent complications and achieve the best outcomes