What is the main cause of intrahepatic jaundice?

Intrahepatic jaundice occurs when there is an impairment in the liver’s ability to process bilirubin, often due to liver cell injury or dysfunction. Genetic disorders can indeed lead to this type of jaundice, as they can affect the liver's ability to conjugate, transport, or excrete bilirubin. Conditions such as Gilbert syndrome, Crigler-Najjar syndrome, and other inherited metabolic errors specifically impact how bilirubin is handled in the body, resulting in elevated bilirubin levels in the blood and subsequently, jaundice.

While other factors like fibrosis of the liver, biliary obstruction, and excessive alcohol consumption can also contribute to liver dysfunction, they tend to lead to other forms of jaundice. For instance, biliary obstruction usually results in extrahepatic jaundice due to blockages in bile flow rather than issues intrinsic to liver cells. Similarly, fibrosis and excessive alcohol consumption can lead to cirrhosis or alcoholic hepatitis, which can cause mixed jaundice but are not solely classified as intrahepatic issues without considering the broader context of liver disease.