What is the most common association with erythema multiforme?

Erythema multiforme is a hypersensitivity reaction that typically manifests as target-like lesions on the skin. While there are several associations with erythema multiforme, mycoplasma pneumonia is notably recognized as one of the most common triggers, especially in children. This association is particularly important because mycoplasma infections can lead to upper respiratory symptoms which then progress to a generalized cutaneous reaction, resulting in the characteristic lesions of erythema multiforme.

The pattern of lesions that occurs in erythema multiforme often aligns with the infective process caused by mycoplasma, making it a significant consideration in clinical settings. Recognizing this association is vital for diagnosis and can guide appropriate treatment, reducing the risk of progression to more severe forms like erythema multiforme major or Stevens-Johnson syndrome.

Other conditions can also be associated with erythema multiforme, such as viral infections, certain medications, and autoimmune diseases, but in the context of this question, mycoplasma stands out as a leading cause.