What is the preferred method for long-term control of asthma in patients with persistent symptoms?

Inhaled corticosteroids are the preferred method for long-term control of asthma in patients with persistent symptoms due to their effectiveness in reducing inflammation and preventing asthma exacerbations. These medications act directly on the airways to decrease inflammation, thereby improving lung function and reducing the frequency of asthma symptoms. By maintaining a consistent presence in the airways, inhaled corticosteroids help to establish a baseline control over airway hyperresponsiveness, which is fundamental in managing chronic asthma.

Inhaled corticosteroids have a well-established safety profile for daily use, making them suitable for long-term management. They also can be paired with other classes of asthma medications if further control is necessary, but the cornerstone of long-term therapy for persistent asthma remains inhaled corticosteroids. Other options, such as short-acting beta agonists, are primarily used for quick relief of acute symptoms rather than as a long-term management strategy. Anticholinergic medications and systemic corticosteroids may be considered in specific situations, but they are not first-line therapies for maintaining control over persistent asthma symptoms.