What triggers are commonly associated with urticaria?

Urticaria, also known as hives, can be triggered by a variety of factors, and certain medications are frequently implicated in its onset. Antibiotics, such as penicillins and sulfonamides, as well as non-steroidal anti-inflammatory drugs (NSAIDs), are well-known triggers. These medications can induce hypersensitivity reactions, leading to the release of histamine and other inflammatory mediators from mast cells, which is responsible for the characteristic wheals and pruritus associated with urticaria.

While environmental allergens and dietary factors can also contribute to urticaria, the specific mention of antibiotics and NSAIDs highlights common medicines that can elicit a direct histamine response. This makes the first choice particularly relevant, given that these drug classes are frequently encountered in both clinical practice and patient medication histories. Recognizing these substances enables healthcare providers to better advise patients on avoiding known triggers and managing their symptoms effectively.