Which antidepressant is FDA approved to assist in treating smoking cessation?

Bupropion, known by the brand name Wellbutrin, is an atypical antidepressant that has been FDA approved to aid in smoking cessation. It works by affecting the neurotransmitters in the brain, particularly dopamine and norepinephrine, which can help to reduce withdrawal symptoms and cravings associated with quitting smoking. This dual action not only contributes to mood stabilization but also decreases the urge to smoke, making it a valuable option in smoking cessation programs.

In contrast, the other medications listed—Citalopram, Fluoxetine, and Sertraline—are selective serotonin reuptake inhibitors (SSRIs) primarily used to treat depression and anxiety disorders. While they may improve mood and help with the emotional aspects of quitting smoking, they are not specifically indicated or proven effective for smoking cessation in the same way that Bupropion is. Thus, Bupropion stands out as the only antidepressant with specific FDA approval for this purpose.