Which antidepressant is noted for having fewer gastrointestinal upset and sexual dysfunction side effects?

Bupropion is favored for its relatively lower incidence of gastrointestinal side effects and sexual dysfunction compared to other antidepressants. It is classified as an atypical antidepressant and primarily works by inhibiting the reuptake of dopamine and norepinephrine, rather than serotonin. This mechanism is associated with a different side effect profile compared to selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), which often contribute to issues like nausea and sexual side effects.

In contrast, other options may have a higher prevalence of gastrointestinal disturbances and sexual side effects. Duloxetine and venlafaxine, both SNRIs, can lead to nausea, constipation, and sexual dysfunction due to their serotonergic activity. Nortriptyline, a tricyclic antidepressant, has its own side effects, including anticholinergic effects, which can also upset the gastrointestinal system.

Overall, bupropion stands out as the option that is associated with fewer of these particular side effects, making it a common choice for patients concerned about such issues while receiving treatment for depression.