Which drug is contraindicated in patients with liver disease and can cause hyperuricemia?

Pyrazinamide is contraindicated in patients with liver disease because it can significantly impair liver function. This drug is metabolized in the liver, and in individuals with pre-existing liver conditions, it poses a risk of exacerbating liver damage. In addition, pyrazinamide is known to lead to hyperuricemia, a condition characterized by elevated levels of uric acid in the blood, which can increase the risk of gout attacks. These factors make pyrazinamide particularly unsuitable for individuals with liver disease, as it may worsen their condition and lead to further complications related to uric acid levels.

In contrast, other options do not directly cause hyperuricemia or are not specifically contraindicated in liver disease the same way pyrazinamide is. For instance, rifampin is primarily a concern for its interactions and effects on liver enzymes but does not cause hyperuricemia like pyrazinamide. Understanding these pharmacological impacts is crucial for selecting appropriate treatments in patients with complex health conditions.