Which of the following benzodiazepines is known for having a serious side effect of hypotension?

Midazolam, also known by its brand name Versed, is a benzodiazepine that is specifically associated with hypotension as a significant side effect. This is particularly relevant in clinical settings, as midazolam is often used for sedation in procedures and can cause a rapid drop in blood pressure, especially when administered intravenously or in higher doses.

The hypotensive effect is thought to be due to the drug's ability to cause vasodilation and decrease systemic vascular resistance, leading to reduced blood pressure. This makes monitoring essential during its use, especially in patients who may already have compromised cardiovascular status or are receiving other medications that can also lower blood pressure.

In contrast, the other benzodiazepines listed, such as alprazolam, lorazepam, and clonazepam, typically do not have hypotension as a clinically significant side effect. While they do have other potential side effects, midazolam’s association with hypotension stands out and is a key consideration for healthcare providers when using this medication.